I hate to play devil's advocate when it comes to injuries but San Jose has 60 players on their roster.
Only 56 saw snaps in preseason week 1.
There was 158 snaps which includes 84 offensive, 50 defensive and 24 special teams snaps.
That's a total of 1,738 plays (158 snaps×11).
40 of the 60 players played 1683 of the 1738 plays or 96.8%.
That means 20 players on the roster played 3.2% of all snaps which includes the 4 players that had 0 plays.
Injured players
Ivan Humphrey 49 plays
Jeffrey Richins 48 plays
Steve Haywood 30 plays
Jarrell Casey 36 plays (no special teams)
Elton Roberts 33 plays
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I get it, injuries **** but there are ways to minimize them especially in the preseason.
Simply stuff like pull starters after 2 quarters, deactivate the 2 pt conversion rule and go for it on 4th down rule. Lower fatigue to 20-25.
****, your LT1 played 91 snaps!!! That was luck he wasn't injured