I just simmed the Seattle/Jacksonville game referenced in the original post using the 0.4.1 game engine as it currently stands. I think you will be relieved to see the result, which is undoubtedly the impact of some of the overuse penalties in play. 23 sacks is still crazy high, but the players giving up the bulk of the sacks have really low pass block rating, one guy as low as 28. If you've got a 28-rated pass blocker and you're throwing lots of passes, especially long ones, expect to have your QB on the ground a lot.