I'd like to see this done via the Rules options.
For example:
Action: Sub-In Backups
Score: Up by X or more
Score: Down by X or more
Time: Less than X to go in X quarter
Then, you could have another rule:
Action: Sub-In Starters
Score: Up by X or less
Time: Any
It would be even better if we could also have a filter for position group. Maybe I want to pull my QB, RB and WR, but leave my OL. Or maybe just pull the offensive starters and leave the defense.