Only 2 ways I've found.
Check out MFN-7 Denver. I stop the pass by murdering the QB and anyone who has ever known him. I mean, to be honest my CBs are decent and my Safeties are really good too... I'm sure that helps... but it's the Sacks and Pressures that set it all up.
Check out MFN-73 Cleveland. I run Dime and Nickel only. I cover the field with 8 people in coverage... some of them not really good... and some how I do rather well not allowing passes. Works great if my Big Play Offense can get ahead and force the other team to throw into it. Works real poorly when the other team gets ahead and grinds out 8 Yards a Carry on me until the clock runs out.