I've generated a list of 50 offensive plays to avoid. Simply put, they are the worst plays and you will seldom have success with them, regardless of who the 11 men you field are.
I generated this list in order to increase the skill floor of owners in this game. While it will take a lot more effort to become a contender across leagues, this is a good starting place for anyone who is struggling to put up winning records. Check through your playbooks and remove any of the plays you see here.
Inside RunsGoal Line Normal HB DiveI Formation Power HB Dive WeakShotgun Normal HB DelaySplit Backs Normal FB Off TackleOutside RunsI Formation 3WR HB Toss StrongI Formation Normal HB Toss WeakStrong I Big HB Sweep StrongStrong I Big HB Toss StrongStrong I Normal FB Trap WeakStrong I Normal HB Power StrongShort PassesI Formation Normal PA Outside CurlsI Formation Normal Strong FloodI Formation Twin WR Strong FloodShotgun 2 RB 3 WR FL DragSingleback Empty 4 Curl FlatsSingleback Normal Quick LooksSingleback Slot Strong HB FlatSingleback Slot Strong Slot CurlSplit Backs Normal CurlsStrong I Big TE DragWeak I Big TE DragMedium PassesI Formation 3WR SE PostI Formation Big TE CurlI Formation Twin WR Hook InsShotgun 2 RB 3 WR WR HooksSplit Backs Normal Overload StrongLong PassesEmpty 4 Wide Spread Deep Corner PostI Formation 3WR WR PostI Formation Big Streak HeavyI Formation Normal PA StreaksI Formation Normal TE OutI Formation Power Play Action BombShotgun 2 RB 3 WR Strong DeepShotgun 4 Wide All GoShotgun 4 Wide WR CornerShotgun 5 Wide 5 WR Corner PostShotgun Normal Deep Weak In and OutSingleback 4 Wide Deep MiddleSingleback Big WR StreaksSingleback Empty 4 TE Deep OutSingleback Empty 4 WR Post CornerSingleback Normal All GoSingleback Normal Deep CornersSingleback Normal FL GoSingleback Slot Strong All GoSplit Backs Normal WR Deep CornerStrong I Normal PA All GoWeak I Big TE Deep PostWeak I Normal All Go