I would suggest there are many opinions on this but I would acquire players with speed at all positions and focus on the skill positions. WR/DL/DB with a QB high in accuracy and intelligence. That’s a good start.
Build speed on the edges and deep D. Be sure not to land in a league with Grandadb....but be sure to land in the same division as Punisher....doesn't get more complex than that. (j/k)
LOL I used to do that for stats manifestation but Punisher has truly updated on his defensive strategies and opened them up.