As JDB said, if you look at the default weights, you'll see the LT is the best pass blocker. I assume most people will either go with the defaults or use them as a sort of model. Therefore, the best pass blocker is normally LT, and the RT is usually more adept at run blocking than pass blocking... again, based on the defaults and generally the way people think about the game.
So, I put my best pass rusher at LDE, to go against the RT. If, during my lengthy scouting, I find that one tackle is much worse at pass blocking, I'll get my best pass rushing DE on that side.
Unless there is a handedness attribute in the game, I would prefer NOT to see a 'blind side' set up. Having handedness AND 'blind side' would be OK, because, again, it forces a team to actually scout and do research to be successful.